Medicare Part D savings are coming soon – Here’s what to know going into 2026.

The Under the Inflation Reduction Act (IRA), signed by President Biden in 2022, allows Medicare to negotiate prescription prices. This change is designed to make medicines more affordable for people on Medicare Part D. This plan is set to take action in 2026, with savings up to 79% since 2023.

Which prescriptions are affected? How much can you expect to save from your Medicare Part D plan? Let’s take a look at how this changes the future of prescription prices.

Savings To Start Soon

The Inflation Reduction Act is set to become effective on January 1, 2026.

For the 54 million people enrolled in Medicare Part D, this act would enforce more cost-effective prescriptions. The Inflation Reduction Act not only caps out-of-pocket costs but also ensures fair pricing through direct negotiation. The prescriptions effected are those without cheaper alternatives. Prices will be updated annually based on inflation and may be revised further through continued negotiations.

For decades, Medicare was barred from negotiating prescription prices. That era is finally over.

The 10 Selected Prescriptions

In 2023, approximately 8.8 million Medicare Part D enrollees used these medications to treat conditions including diabetes, heart failure, blood clots, and cancer. These 10 prescriptions alone accounted for $56.2 billion in gross prescription costs—20% of all Medicare Part D spending that year.

Here are the 10 Prescriptions selected:

Table view:

Name	Type	$ Price Before	$ Price After
Eliquis	blood thinner	$521	$231
Xarelto	blood thinner	$517	$197
Januvia	diabetes	$527	$113
Jardiance	diabetes	$573	$197
Enbrel	rheumatoid arthritis	$7,106	$2,355
Imbruvica	blood cancers	$14,934	$9,319
Farxiga	diabetes, heart failure and chronic kidney disease	$556	$178
Entresto	heart failure	$628	$295
Stelara	psoriasis and Crohn’s disease	$13,836	$4,695
Fiasp and NovoLog	diabetes	$495	$119

On average, the negotiated prices are more than 50% lower than the current list prices. In 2023, these 10 alone accounted for $56.2 billion in total Medicare Part D costs, about 20% of total prescription spending under the program. Nearly 9 million people used at least one of these prescriptions that year.

How the Process Worked

CMC looked at a range of data, including how much each prescription costs to make, its effectiveness compared to other treatments, and even what patients and doctors had to say. CMS then sent an initial price offer to each company. The companies had a chance to respond with a counteroffer, and CMS met with each of them multiple times to talk through the numbers and reach a fair price.

Both sides agreed on a price during those meetings. For the other five, CMS made a final written offer—and each company accepted by the deadline. This process showed that it’s possible to balance fair prices with support for continued prescription innovation.

What’s Next?

This is just the beginning. CMS is already preparing for the next round of negotiations, which will lead to more savings starting in 2027. Each year, new prescriptions will be added to the negotiation process, and prices will be updated based on inflation and other factors.

Medicare’s ability to negotiate prices is a major win for individuals on Part D of Medicare. It’s a long-overdue step toward making prescriptions more affordable and protecting the Medicare program for generations to come.